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. 2020 Jun 25;9(6):1987. doi: 10.3390/jcm9061987

Figure 1.

Figure 1

Representative reflectance confocal microscopy (RCM) images of actinic cheilitis (AC) and lip squamous cell carcinoma (SCC), and histological correspondents. (A) RCM image of an atypical honeycomb pattern of the stratum granulosum, seen in an AC lesion. (B) RCM image at the stratum spinosum showing an atypical honeycomb pattern, which can be seen in either AC or SCC. (C) Histopathology image illustrating parakeratosis, atypical keratinocytes in the stratum granulosum and spinosum, spongiosis, and intradermal inflammatory infiltrate in an AC lesion (haematoxylin-eosin, cropped, original magnification 40×). (D) RCM image of the complete architectural disarray in the granular layer of a lip SCC. (E) RCM image showing disarray in the stratum spinosum, in a SCC lesion. (F) Histopathological image displaying infiltrative atypical polygonal squamous cells with distinct cell borders, abundant eosinophilic cytoplasm, and large vesicular nuclei with moderate nuclear pleomorphism in a SCC (haematoxylin-eosin, cropped, original magnification 40×) (G,H). RCM images showing tumor nests (white asterisks) surrounded by white areas corresponding to fibrosis at the level of the dermis, in a SCC. (I) Histopathology image illustrating invasive SCC nests and strands of atypical polygonal squamous cells surrounded by intradermal inflammatory infiltrate in a lip SCC (haematoxylin–eosin, cropped, original magnification 100×).