Table 1.
Summary of proteomics studies for milk-derived EVs from various species.
| Milk Source | Main Proteins Implicated | Method of Isolation and Characterization | Reference |
|---|---|---|---|
| Bovine | Butyrophillin, Xanthine Oxidase, Adipophilin, Lactadherin |
Differential centrifugation, ultracentrifugation, sucrose gradient, LC-MS/MS | [108] |
| Bovine (S. aureus infected cows) |
Butyrophillin, Xanthine dehydrogenase, Lactadherin, fatty acid synthase |
Differential centrifugation, ultracentrifugation, sucrose gradient, LC-MS/MS |
[130] |
| Human | CD9, Annexin A5, Flotillin-1, CD83, CD81, Lactadherin, Syntenin, Rab, Ras-related proteins | Differential centrifugation, ultracentrifugation, sucrose gradient, LC-MS/MS |
[123] |
| Horse | CD81, CD63 receptors, Beta-Lactoglobulin, Lactadherin, Butyrophillin, Lactoferrin, Xanthine dehydrogenase | Differential centrifugation, ultracentrifugation, sucrose gradient, MALDI MS/MS |
[107] |
| Porcine | CD9, CD63, HSPs, Lactadherin, Butyrophillin, Adipophilin, Xanthine oxidase | Differential centrifugation, ultracentrifugation, sucrose gradient, LC-ESI-MS/MS |
[106] |
| Human | MHC II, CD81, MUC-1, HSPs, CD63, Butyrophillin, Lactadherin | Differential centrifugation, ultracentrifugation, sucrose gradient, LC-MS/MS |
[42] |
| Bovine | Butyrophillin, Xanthine Oxidase, Adipophilin, Lactadherin, Rab GTPases, integrins |
Differential centrifugation, ultracentrifugation, sucrose gradient, LC-MS/MS |
[66] |