Table 2.
Changes in resting hemodynamics.
| Control (N = 11) |
Riociguat (N = 10) |
P value | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Follow-up | P value | Baseline | Follow-up | P value | ||
| mPAP (mmHg) | 25 ± 4 | 25 ± 3 | 0.51 | 25 ± 5 | 27 ± 5 | 0.23 | 0.43 |
| PAWP (mmHg) | 11 ± 3 | 13 ± 3 | <0.01 | 12 ± 4 | 16 ± 5 | 0.16 | 0.51 |
| CO (L/min) | 4.0 ± 1.0 | 3.7 ± 1.4 | 0.40 | 3.9 ± 1.1 | 4.8 ± 0.8 | 0.08 | 0.05 |
| TPG (mmHg) | 14 ± 4 | 12 ± 4 | 0.06 | 12 ± 3 | 10 ± 5 | 0.31 | 0.89 |
| PVR (Wood units) | 3.8 ± 1.9 | 3.8 ± 2.1 | 0.98 | 3 ± 1.3 | 2.5 ± 0.6 | 0.29 | 0.25 |
| sBP (mmHg) | 148 ± 16 | 156 ± 11 | 0.04 | 133 ± 19 | 138 ± 25 | 0.85 | 0.51 |
| dBP (mmHg) | 69 ± 6 | 71 ± 7 | 0.39 | 74 ± 17 | 67 ± 13 | 0.08 | 0.03 |
| HR (/min) | 64 ± 8 | 62 ± 7 | 0.10 | 63 ± 6 | 66 ± 8 | 0.13 | 0.03 |
| SatO2 (%) | 95 ± 1.2 | 95 ± 1.4 | 0.98 | 95 ± 3 | 95 ± 2 | 0.88 | 0.87 |
Continuous variables are expressed as mean ± SD.
BP, blood pressure; CO, cardiac output; HR, heart rate; mPAP, mean pulmonary arterial pressure; PAWP, pulmonary arterial wedge pressure; PVR, pulmonary vascular resistance; SatO2, arterial oxygen saturation; TPG, trans-pulmonary pressure gradient.