Table 3.
Changes in exercise capacity and RV function.
| Control (N = 11) |
Riociguat (N = 10) |
P value | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Follow-up | P value | Baseline | Follow-up | P value | ||
| WHO functional class (I/II) | 7/4 | 7/4 | 1 | 5/5 | 6/4 | 1 | – |
| 6MWD (m) | 527 ± 65 | 535 ± 62 | 0.29 | 589 ± 95 | 595 ± 72 | 0.08 | 0.06 |
| peak VO2 (ml/min/kg) | 14.9 ± 3.3 | 14.6 ± 2.6 | 0.69 | 15.9 ± 3 | 14.5 ± 2.1 | 0.12 | 0.27 |
| VE vs. VCO2 slope | 37.4 ± 5.2 | 32.7 ± 4.2 | 0.01 | 36.2 ± 4.8 | 34.5 ± 4.1 | 0.20 | 0.14 |
| RVEF (%) | 57.6 ± 8.8 | 56.2 ± 4.7 | 0.65 | 57.1 ± 8.2 | 57.4 ± 11.1 | 0.85 | 0.61 |
Continuous variables are expressed as mean ± SD.
RVEF, right ventricular ejection fraction; VCO2, carbon dioxide production; VO2, oxygen uptake; VE, minute ventilation; 6MWD, 6-min walk distance.