Table 2.
Experimental runs, variables levels, and observed responses of FLB niosomes prepared according to the Box–Behnken design.
| Experimental Run # | Independent Variables | Vesicle Size (nm) ± SD # |
Entrapment Efficiency (%) ± SD & | ||
|---|---|---|---|---|---|
| Span® 85 conc. (µM) | Hydration Time (min.) | Hydrating Buffer pH | |||
| F1 | 1.00 | 37.50 | 3.00 | 272.4 ± 8.56 | 51.7 ± 1.23 |
| F2 | 3.50 | 15.00 | 3.00 | 114.3 ± 2.35 | 60.3 ± 1.98 |
| F3 | 6.00 | 60.00 | 6.00 | 46.2 ± 2.14 | 94.3 ± 1.56 |
| F4 | 3.50 | 37.50 | 6.00 | 118.4 ± 5.28 | 68.8 ± 0.98 |
| F5 | 1.00 | 15.00 | 6.00 | 191.6 ± 3.56 | 53.7 ± 0.78 |
| F6 | 3.50 | 37.50 | 6.00 | 119.4 ± 1.47 | 69.9 ± 3.42 |
| F7 | 3.50 | 15.00 | 9.00 | 112.4 ± 1.89 | 71.5 ± 2.67 |
| F8 | 6.00 | 37.50 | 3.00 | 56.7 ± 2.19 | 82.3 ± 3.99 |
| F9 | 3.50 | 37.50 | 6.00 | 102.8 ± 1.59 | 68.6 ± 3.12 |
| F10 | 3.50 | 60.00 | 9.00 | 110.4 ± 3.36 | 75.3 ± 2.59 |
| F11 | 3.50 | 37.50 | 6.00 | 117.9 ± 1.98 | 67.7 ± 2.11 |
| F12 | 6.00 | 37.50 | 9.00 | 107.6 ± 2.11 | 98.5 ± 4.67 |
| F13 | 3.50 | 37.50 | 6.00 | 120.8 ± 0.98 | 69.5 ± 2.54 |
| F14 | 6.00 | 15.00 | 6.00 | 61.3 ± 4.45 | 86.6 ± 4.17 |
| F15 | 3.50 | 60.00 | 3.00 | 115.6 ± 3.65 | 65.7 ± 2.97 |
| F16 | 1.00 | 37.50 | 9.00 | 205.6 ± 5.43 | 59.5 ± 3.32 |
| F17 | 1.00 | 60.00 | 6.00 | 196.2 ± 6.43 | 55.6 ± 2.47 |
Abbreviations: FLB, Flibanserin; SD, standard deviation; Results are presented as mean ± SD, # n = 5, & n = 3.