Table 3.

Statistical analysis of FLB niosomes responses according to the quadratic model.

Responses	Sequential P-Value	Lack of Fit P-Value	R2	Adjusted R2	Predicted R2	Adequate Precision	PRESS	Significant Terms
Y1: Vesicle size (nm)	<0.0001	0.4821	0.9930	0.9840	0.9461	39.7231	2905.48	X1, X1X3, X12, X22, X32
Y2: Entrapment Efficiency (%)	0.0001	0.5436	0.9984	0.9963	0.9885	73.9908	33.33	X1, X2, X3, X1X2, X1X3, X12

Abbreviations: FLB, Flibanserin; PRESS, predicted residual error sum of squares.