Table 4.

Statistical analysis of variance (ANOVA) of the responses (Y₁ and Y₂) results.

Factors	Disintegration Time (Y1), min			Cumulative Release after 60 min (Y2), %
	Estimate	F-Ratio	p-Value	Estimate	F-Ratio	p-Value
X1	−190.0	2166.00	0.0001 *	35.83	311.63	0.0001 *
X2	35.0	73.50	0.0004 *	−3.58	3.10	0.1384
X3	65.0	253.50	0.0001 *	−8.5	17.54	0.0086 *
X1X1	50.83	71.56	0.0004 *	−2.83	0.90	0.3864
X1X2	5.0	0.75	0.4261	−0.9	0.10	0.7665
X1X3	−55.0	90.75	0.0002 *	0.05	0.00	0.9868
X2X2	10.83	3.25	0.1313	−2.83	0.90	0.3864
X2X3	15.0	6.75	0.0484 *	−1.35	0.22	0.6579
X3X3	10.83	3.25	0.1313	9.72	10.58	0.0226 *
R2	99.81			98.58
Adj. R2	99.48			96.01
SEE	5.77			2.87
MAE	2.44			1.23

Note: * Significant effect of factors on individual responses. Abbreviations: X₁, croscarmellose sodium percentage; X₂, gelatin solution concentration; X₃, Hydroxypropyl methylcellulose percentage; X₁X₂, X₁X₃, X₂X₃, the interaction term between the factors; X₁X₁, X₂X₂, and X₃X₃, the quadratic terms between the factors; R², R-squared; Adj-R², adjusted R-squared; SEE, standard error of estimate; MAE, mean absolute error.