Table 1.
Metabolites that differentiate the healthy cornea (HC) from keratoconus (KC).
| Metabolite Name | Class | HC Mean Abundance |
KC Mean Abundance |
HC/KC | |
|---|---|---|---|---|---|
| FC | p-Value | ||||
| Benzoic acid | Carboxylic acids | 180 | 119 | 1.51 | 0.0338 |
| Glycolic acid | Carboxylic acids | 6.18 | 2.65 | 2.33 | 0.0258 |
| Succinic acid | Carboxylic acids | 771 | 536 | 1.44 | 0.0096 |
| Gluconic acid | Carboxylic acids | N.D. | 0.56 | - | - |
| Linoleic acid | Fatty acids | 103 | 38.8 | 2.65 | 0.0144 |
| Myristic acid | Fatty acids | 175 | 112 | 1.56 | 0.0197 |
| Palmitic acid | Fatty acids | 7240 | 4250 | 1.70 | 0.0042 |
| Pentadecanoic acid | Fatty acids | 122 | 74.3 | 1.64 | 0.0163 |
| Stearic acid | Fatty acids | 7440 | 4810 | 1.55 | 0.0159 |
| trans-13-Octadecenoic acid | Fatty acids | 149 | 83.3 | 1.79 | <0.0001 |
| Petroselinic acid | Fatty acids | 256 | N.D. | - | - |
| Cholesta-3,5-diene—isomer 1 | Sterols | 83.6 | 17.6 | 4.75 | 0.0032 |
| Cholesta-3,5-diene—isomer 2 | Sterols | 421 | 85.5 | 4.92 | 0.0016 |
| Cholesterol | Sterols | 5680 | 1960 | 2.90 | 0.0218 |
| Cholesterol propionate | Sterol esters | N.D. | 0.12 | - | - |
| Hexadecanol | Alcohols | 109 | 76.3 | 1.43 | 0.0147 |
| Phosphoric acid | Others | 56,900 | 67,700 | 0.84 | 0.0228 |