Table 3.

Altered expression of the 14-3-3 genes in individuals with schizophrenia or autism spectrum disorder.

Gene Symbol	Disorder	FC &	p-Value	FDR	Probe	Tissue	Study (PMID) or GEO ID	Sample, Cases vs. Controls
YWHAB	SCZ	−1.06	2.51 × 10−3	0.10	8062880	cerebellum	GSE35978	44 SCZ vs. 50 control
YWHAB	SCZ	−1.41	0.001	0.02	217717_s_at *	hippocampus	GSE53987	15 SCZ vs. 18 control
YWHAB	ASD	N/A	N/A	1.43 × 10−3	N/A	cortex (BA19, BA10, BA44)	Gupta et al., 2014 (25494366)	32 ASD vs. 40 control
YWHAE	ASD	−1.34	0.003	0.06	ILMN_1807535	cerebellum	GSE38322	15 ASD vs. 12 control
YWHAE	SCZ	−1.52	1.93 × 10−4	0.01	210317_s_at	hippocampus	GSE53987	15 SCZ vs. 18 control
YWHAE	SCZ	−1.10	3.31 × 10−4	0.04	11753092_s_at *	DLPFC	GSE87610	65 SCZ vs. 72 control
YWHAH	SCZ	−1.68	6.69 × 10−5	0.01	201020_at	hippocampus	GSE53987	15 SCZ vs. 18 control
YWHAH	ASD	N/A	<0.01	<0.078	N/A	DLPFC	Liu et al., 2016 (27685936)	34 ASD vs. 40 control
YWHAQ	SCZ	−1.02	0.004	0.03	N/A	frontal and temporal cortex	Gandal et al., 2018 (30545856)	560 SCZ vs. 936 control
YWHAQ	SCZ	−1.34	2.34 × 10−5	0.01	200693_at *	hippocampus	GSE53987	15 SCZ vs. 18 control
YWHAZ	ASD	−1.61	3.01 × 10−5	0.01	ILMN_1669286	cerebellum	GSE38322	14 ASD vs. 12 control
YWHAZ	SCZ	−1.87	3.07 × 10−5	0.01	200641_s_at *	hippocampus	GSE53987	15 SCZ vs. 18 control
SFN	ASD	2.18	0.001	0.03	N/A	frontal and temporal cortex	Gandal et al., 2018 (30545856)	51 ASD vs. 936 control
SFN	SCZ	1.34	7.69 × 10−5	1.33 × 10−3	N/A	frontal and temporal cortex	Gandal et al., 2018 (30545856)	559 SCZ vs. 936 control
SFN	SCZ	1.53	0.010	0.08	33323_r_at *	hippocampus	GSE53987	15 SCZ vs. 18 control

ASD, autism spectrum disorder; SCZ, schizophrenia; FDR, false discovery rate; ^& FC, fold change was calculated when log2FC was provided in the study; N/A, data not available; * Genes showing significant differential expression in independent probe sets targeting different transcripts/exons of the same gene, data shown corresponding to the probe with the highest fold-change.