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. 2020 Jun 5;9(6):1746. doi: 10.3390/jcm9061746

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Algorithm chart for early brain injury severity prognostication. Early brain injury (EBI) severity prognostication and the proposed resulting management strategies are presented based on early S100B serum concentration. Low S100B: concentrations below the lower threshold of the gray zone rejecting severe EBI; high S100B: concentrations above the upper threshold of the gray zone predicting severe EBI. An S100B concentration within the gray zone has an uncertain diagnostic value but suggests significant brain injury. EEG: electroencephalography; ICH: intracerebral hematoma; TCD: transcranial doppler.