Table 2.
Accuracy of maximal S100B and GCS at ICU admission to predict an M-GCS < 6 on day 3 in the whole cohort and only in patients with an M-GCS < 6 at ICU admission.
| All Patients (n = 81, M-GCS < 6 at Day 3 n = 12) |
Patients with M-GCS < 6 at Admission (n = 25, M-GCS < 6 at Day 3 n = 9) |
|||
|---|---|---|---|---|
| S100B Max | GCS at Admission | S100B Max | GCS at Admission | |
| AUC, % (95% CI) | 86.7 (73.6;95.9) | 84.1 (73.9–92.6) | 88.2 (72.2;100) | 62.5 (53.1;72.0) |
| Best threshold (95% CI) | 0.165 µg/L (0.100;0.494) |
4.5 (4.5–14.5) | 0.336 µg/L (0.123;0.951) |
4.5 (4.5;8.5) |
| Se, % (95% CI) | 83.3 (58.3;100) | 75.0 (50;100) | 77.7 (44.4;100) | 100 |
| Sp, % (95% CI) | 73.9 (62.3;84.1) | 82.6 (73.9;91.3) | 93.8 (81.3;100) | 25 (6.3;43.8) |
| PLR (95% CI) | 3.2 (2.0;5.1) | 4.3 (2.3;7.9) | 12.4 (1.8;85.7) | 1.3 (0.9–1.8) |
| NLR (95% CI) | 0.23 (0.06;0.81) | 0.30 (0.11;0.81) | 0.24 (0.07;0.81) | 0.19 (0.01;3.14) |
| Gray zone µg/L | 0.104–0.256 | 13.5–4.5 | 0.144–0.336 | 4.5–3 |
| Inter-LHR | 0.16–5.75 | 0.25–4.32 | 0.22–12.4 | 1.2–0.19 |
| % in gray zone | 38 | 14 | 32 | 84 |
The gray zones of diagnostic uncertainty are presented with the percentage of patients inside, and their interval likelihood ratio (inter-LHR). The positive LHR of the highest value of the biomarker in the gray zone is considered to include the diagnosis and the negative LHR of the lowest value to exclude the diagnosis. AUC: area under the curve, 95% CI: 95% confidence interval, Se: sensitivity, Sp: specificity, PLR: positive likelihood ratio, NLR: negative likelihood ratio.