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Effect of UDCA treatment on oxidative stress in OIR mice. Frozen retinal sections from control mice at P17 (room air), OIR mice, and OIR mice treated with 50 mg/kg UDCA (P7–P17) were stained with (A) dihydroethedium (DHE) and (B) 4-hydroxynonenal (4-HNE) to assess oxidative stress. (C) Dot blot assay assessing 4-HNE and 3-nitrotyrosine (3-NT) levels from total protein fractions extracted from control mice (room air), OIR mice at P17, and OIR mice treated with 50 mg/kg UDCA (P7–P17).
