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. 2020 Jun 19;9(6):1921. doi: 10.3390/jcm9061921

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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UDCA regulates STAT3 (Signal transducer and activator of transcription 3) signaling to reduce inflammation in OIR mice. Total protein fractions from control mice (room air), OIR mice, and OIR mice treated with 50 mg/kg UDCA (P7–P17) at P17 were used to analyze protein levels of VEGF₁₆₅ (A), pSTAT3, and STAT3 (C) by Western blotting. (B–D) Densitometry graphs showing changes in protein expressions. (E–G) The total retinal extracts were used to quantify protein levels of vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNFα), and interleukin 6 (IL-6) using ELISA assay. Values are mean ± S.D (n = 6 retinas per group). * p < 0.05 vs. control and # p < 0.05 vs. OIR.