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. 2020 Apr 9;7(2):36. doi: 10.3390/bioengineering7020036

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Clinical applications for hPSC-derived hepatic cells and liver organoids. Isolated somatic cells from patients can be cultured and reprogrammed into patient-specific hiPSCs. These cells represent a promising cell source for cell therapy, as differentiated hepatocytes can be used for transplantation in regenerative medicine strategies. Additionally, differentiated hepatic cell lineages or generated liver organoids can be applied in disease modelling, as well as drug development and hepatotoxicity assays.