Table 1.

Summary of substitutions at N9, N6, C2, and C8 atoms, and their combinations, that resulted in compounds with significantly higher activity than appropriate standards in indicated CK bioassays.

Bioassay	Std.	Position of the Substituent on the Purine Ring				Ref.
		N9	N6	C2	C8
Amaranthus caudatus betacyanin	BAP	β-D-ribofuranosyl-	2-chlorobenzyl-, 3-chlorobenzyl-, 2-bromobenzyl-, 3-bromobenzyl-, 3-iodobenzyl-, 3,5-difluorobenzyl-, 2,4,5-trifluorobenzyl-, 2-chloro-4-fluorobenzyl-, 2-trifluoromethylbenzyl-, 3-trifluoromethoxybenzyl-	H	H	[45]
			2-fluorobenzyl-, 3-fluorobenzyl-, 4-fluorobenzyl-, 2-chlorobenzyl-, 3-chlorobenzyl-, 2-bromobenzyl-, 3-bromobenzyl-, 4-bromobenzyl-, 3-iodobenzyl-	Cl	H	[46]
		2′-deoxy-β-D-ribofuranosyl-	3-hydroxybenzyl-, 2-fluorobenzyl-, 4-fluorobenzyl-, 2-chlorobenzyl, 3-chlorobenzyl-, 2-bromobenzyl-, 3-brombenzyl-, 2-methybenzyl-, 2-trifluoromethylbenzyl-	H	H	[120]
		tetrahydropyran-2-yl	isopentenyl-, furfuryl-	H	3-aminopropyl-, 4-aminobutyl-, methylsulfanyl-, dimethyl-, allyl-	[172]
			benzyl-	H	H	[147]
		tetrahydrofuran-2-yl	benzyl-, 2-methoxybenzyl-, 3-methoxybenzyl-	H	H	[147]
			thiofen-2-yl-	Cl	H	[176]
	iP	tetrahydropyran-2-yl, ethoxyethyl-, 2-bromoethyl-, 2-chloroethyl-, 4-ethoxy-4-oxobutyl-	isopentenyl-	H	H	[158]
Senescence (WLS)	BAP	β-D-ribofuranosyl-	2-fluorobenzyl-, 3-fluorobenzyl-, 4-fluorobenzyl-, 2-chlorobenzyl-, 4-chlorobenzyl-, 2-methylbenzyl-, 3-methybenzyl-, 2-methoxybenzyl-, 3-methoxybenzyl-, 3,4-dichlorobenzyl-, 2,3-dimethoxybenzyl-, 2,4-difluorobenzyl-, 3,5-difluorobenzyl-, 2,3,4-trifluorobenzyl-, 2,3,6-trifluorobenzyl-, 2-chloro-4-fluorobenzyl-, 3-chloro-4-fluorobenzyl-, 2-hydroxy-5-methylbenzyl-, 2-difluoromethoxybenzyl-	H	H	[45]
			2-fluorobenzyl-, 3-fluorobenzyl-, 4-fluorobenzyl-, 2-chlorobenzyl-, 3-chlorobenzyl-,4-chlorobenzyl-, 3-bromobenzyl-, 4-bromobenzyl-	Cl	H	[46]
		β-D-arabinofuranosyl-	benzyl-, 2-fluorobenzyl-, 3-fluorobenzyl-, 4-fluorobenzyl-, 3-chlorobenzyl-, 2-methoxybenzyl-,3-methoxybenzyl-, 3-hydroxybenzyl-, 3-methylbenzyl-, 2,5-difluorobenzyl-, 3,5-difluorobenzyl-	H	H	[134]
		2′-deoxy-β-D-ribofuranosyl-	benzyl-, 2-hydroxybenzyl-, 3-hydroxybenzyl-, 4-hydroxybenzyl, 3-methoxybenzyl-, furfuryl- 2,5-dimethoxybenzyl-, 2-fluorobenzyl-, 3-fluorobenzyl-, 4-fluorobenzyl-, 2-chlorobenzyl-, 3-chlorobenzyl-, 4-chlorobenzyl-, 2-bromobenzyl-, 3-bromobenzyl-, 4-bromobenzyl-, 2-methylbenzyl-, 3-methylbenzyl-, 2-trifluoromethylbenzyl-, 3-trifluoromethylbenzyl-,	H	H	[120]
		tetrahydropyran-2-yl	benzyl-, 3-hydroxybenzyl-, 2-methoxybenzyl-,	H	H	[147]
		tetrahydrofuran-2-yl	benzyl-, 3-hydroxybenzyl-	H	H	[147]
			tetrahydrofuran-2-yl-, thiofen-2-yl-, 5-methylthiofen-2-yl-	H	H	[176]
			tetrahydrofurfuryl-	Cl	H	[176]
	Kin	2-bromoethyl-, 2-chloroethyl-, 4-chlorobutyl-, 1-ethoxyethyl-, tetrahydrofuran-2-yl	furfuryl-	H	H	[157]
Tobaccocallus	BAP	β-D-ribofuranosyl-	2-fluorobenzyl-, 4-fluorobenzyl-, 2-bromobenzyl-, 2-methoxybenzyl-	H	H	[45]
			2-flourobenzyl-, 3-fluorobenzyl-, 4-fluorobenzyl-, 2-chlorobenzyl-, 3-chlorobenzyl-, 4-bromobenzyl-	Cl	H	[46]
		2′-deoxy-β-D-ribofuranosyl-	benzyl-, 4-fluorobenzyl-, furfuryl-	H	H	[120]
		tetrahydropyran-2-yl	isopentenyl-, furfuryl-	H	2-aminoethyl-, 3-aminopropyl-, 4-aminobutyl-, 6-aminohexyl-, methoxy-, 2-hydroxyethyl-	[172]
			benzyl-	H	H	[147]
		tetrahydrofuran-2-yl	furfuryl-, thiofen-2-yl, 5-hydroxymethylfuran-2-yl-	H	H	[176]
			furfuryl-, tetrahydrofurfuryl-, thiofen-2-yl-	Cl	H	[176]
	iP	ethoxyethyl-, acetoxy-, 2-azidoethyl-, 4-chlorobutyl-, 3-cyanopropyl-	isopentenyl-	H	H	[158]
	Kin	2-bromoethyl, 2-chloroethyl-, 1-ethoxyethyl-, tetrahydrofuran-2-yl	furfuryl-	H	H	[157]