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Relative risk of increased alanine aminotransferase with different cofounding factors in induced blood-stage malaria models
| Risk factors | Grade 2, 3, or 4 ALT (n = 20) | Normal or grade 1 ALT (n = 94) | Relative risk (95% CI) | P-value |
|---|---|---|---|---|
| Parasitemia ≥ 10,000 parasites/mL | 19 | 72 | 4.8 (0.68 to 34.0) | 0.116 |
| Acetaminophen > 6 g | 4 | 6 | 2.6 (1.08 to 6.29) | 0.034 |
| Parasitemia ≥ 10,000 parasites/mL plus acetaminophen > 6 g | 4 | 5 | 2.9 (1.24 to 6.88) | 0.015 |
ALT = alanine aminotransferase.
