Table 1.
Recipients | Donors | |
---|---|---|
Screening criteria step 1 | Aged 18–38 years Presenting with directed donors BMI < 30 MRKH type 1 Or MRKH type 2 with unique orthotopic kidney Or after hysterectomy for cervical cancer stage IA (FIGO 2018) remission, 5 years no radiation therapy No children In stable partnership No treatment ABO group Compatibility with the donor Residual vagina 6 cm or more beneficiary of a social security No severe comorbidities No associated malformations No azoospermia in the partner No history of cancer (except cervical cancer) No history of transfusion No history of complex abdominal or pelvic surgery No sigmoid colpoplasty No transmissible infectious diseases in the couple No smoking, no history of active drug abuse or alcoholism Couple speaking French. |
Aged 40–65 years Directed with recipient BMI < 30 Having at least one child in good health (no recurrent miscarriages, no premature deliveries, no preeclampsia, no Caesarian) ABO group Compatibility with the donor beneficiary of a social security No severe comorbidities No history of cancer No uterine scarring and major uterine surgery No history of conization No uterine disease No transmissible infectious diseases No History of major abdominal or pelvic surgery No smoking, no history of active drug abuse or alcoholism Speaking French. |
Screening criteria step 2 | Favorable psychological assessment Recipient and partner having given their informed consent to participate in the study Multidisciplinary comity agreement |
Favorable psychological assessment Donor having given her informed consent to participate in the study Multidisciplinary comity agreement |
Inclusion criterias step 1 | Normal thrombophilia tests HLA compatibility with donor Negative HPV oncogene test Negative PCR herpes simplex viruses 1 and 2 test No gynecologic infection No transmissible infectious diseases in the couple Good ovarian reserve: AMH > 1.5, AFC > 10 Normal pelvic ultrasound No diabetes Good renal, hepatic function Normal hemostasis Normal spermogram for the partner |
Normal vaginal smear HLA compatibility with recipient Negative HPV oncogene test Negative PCR herpes simplex viruses 1 and 2 test No gynecologic infection No transmissible infectious diseases Positive CMV and/or EBV serologies (if the recipient is negative) Positive HHV8 serology (if the recipient is negative) Normal pelvic ultrasound No diabetes Good renal, hepatic function Normal hemostasis Normal endometrial biopsy |
Inclusion criteria step 2 | Normal echocardiogram Normal abdominal and pelvis MRI Normal Chest X-ray |
Good quality uterine vessels as examined by angio-MRI, angio-CT scan and arteriography Normal abdominal and pelvis MRI Normal echocardiogram Normal neck vessels sonography Normal mammogram Normal abdominal ultrasound Normal Chest X-ray |
Definitive inclusion | At least 10 frozen embryos with IVF Normal tests 7 days before surgery |
Normal tests 7 days before surgery |