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. 2020 Jun 17;9(6):1900. doi: 10.3390/jcm9061900

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Principle features of the two different subtypes described in the dualistic classification model of endometrial cancer (EC) by Bokhman et al. [7] (A) Risk factors, molecular characteristics and prognosis of the dualistic classification. (B) Deconstruction of the dualistic model according to the different histological grades that exist on endometrioid-endometrial cancers (EECs) and the two most common histological subtypes of non-endometrioid endometrial cancers (NEECs). PX: prognosis; OS: overall survival; SEC: serous EC; CC: clear cell EC; EIN: endometrial intraepithelial neoplasia; MSI: microsatellite stability instable; SCNAs: somatic copy number alterations load; Sp.Mlc.alterations: specific molecular alterations; MMR: miss-match repair proteins: SEIN: serous endometrial intra-neoplasia; LN: lymph node status; +++: present/high; ++ frequent; + occasional; - absent/low.