Figure 7.

Overview of the validated biomarkers. (A) Full perspective of all validated biomarkers: (i) dark red when protein was validated five or more times for that parameter; (ii) red: when protein was validated in more than one study; (iii) light red: protein validated in one study. List of the top-25 most studied proteins as prognostic factor biomarkers is zoomed in. For each protein, the number of studies in which it was validated appears; (B) list of proteins validated, at least in one study, for one of the considered parameters. Ordered regarding the number of independent studies where they were validated. In bold, the top-25 most studied proteins; (C) EC disease Pathway Map obtained from the KEGG DISEASE database [30,59,60]. The proteins from the 11 most studied proteins list are highlighted by yellow stars, while the top-25 are highlighted by blue stars. HT: histological type; HG: histological grade; Fs: FIGO stage; MI: myometrial invasion; LNS: lymph node status; LVSI: lymphovascular space invasion; CI: cervical invasion; M: metastasis; TCGA: TCGA classification; R: recurrence; DFS: disease-free survival; DSS: disease-specific survival; OS: overall survival; PFS: progression-free survival; RFS: recurrence-free survival.