Figure 5.

Plot of the residue-specific ¹³C chemical shift deviation for membrane-associated Aβ₄₀ fibrils derived from MM1 (the fibrils grown from phosphatidylcholine (PC) model bilayers). The comparison contains two types of fibrils from current studies: those grown from the MM2 model bilayer (black) and those grown from the extracted synaptic membranes BM2 (red), and three fibrils reported in the literature: the three-fold Aβ₄₀ fibrils grown from synthetic peptides (green) [35], the first molecular structure from human-brain-seeded Aβ₄₀ fibril (blue) [6] and the reported predominant structure from multiple human brain tissue samples (purple) [8]. The dashed lines represent the thresholds of significant chemical shift difference for individual residues, by considering the ssNMR line widths.