Table 2.
Parameters associated with elevated plasma high-sensitivity troponin (hsTnT) levels in 70 patients with Friedreich ataxia. NT-proBNP: N-terminal pro-brain natriuretic peptide; LV: left ventricle.
| Parameters | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| OR (95%IC) | p | OR (95%IC) | p | |
| Age | 0.96 (0.92–1.00) | 0.05 * | - | NS |
| Male sex | 0.88 (0.33–2.34) | 0.79 | ||
| Body surface area | 0.40 (0.02–7.08) | 0.36 | ||
| GAA1 | 1.47 (0.67–3.18) | 0.29 | ||
| GAA2 | 1.32 (0.69–2.55) | 0.72 | ||
| Heart rate | 1.02 (0.98–1.06) | 0.31 | ||
| NT-proBNP plasma level ≥ 125 ng/L | 2.34 (0.63–8.61) | 0.20 | ||
| Septal wall thickness | 1.79 (1.27–2.53) | <0.001 * | 1.79 (1.27–2.53) | <0.001 |
| Posterior wall thickness | 1.38 (1.01–1.88) | 0.04 * | - | NS |
| Relative wall thickness (RWT) > 0.42 | 2.64 (0.83–8.34) | 0.1 | - | |
| LV diastolic diameter | 0.99 (0.9–1.09) | 0.66 | ||
| LV systolic diameter | 1.06 (0.97–1.15) | 0.19 | ||
| LVejection fraction | 0.91 (0.84–1.00) | 0.17 | ||
| LV mass index | 1.04 (1.01–1.08) | <0.001 * | - | NS |
| Trans mitral E wave | 0.1 (0.001–6.06) | 0.59 | ||
| Trans mitral A wave | 0.32 (0.01–6.84) | 0.53 | ||
| E/A ratio | 1.27 (0.58–2.77) | 0.6 | ||
| Lateral E/E’ ratio | 1.1 (0.86–1.51) | 0.5 | ||
* variables included in the multivariate analysis. NS: non significant.