Table 3.
Parameters associated with elevated plasma NT-proBNP levels in 85 patients with Friedreich ataxia.
| Parameters | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| OR (95%IC) | p | OR (95%IC) | p | |
| Age | 0.99 (0.94–1.04) | 0.72 | ||
| Male sex | 2.42 (0.67–8.76) | 0.17 | ||
| Body surface area | 1.34 (0.03–48.7) | 0.87 | ||
| GAA1 | 4.10 (1.25–13.38] | 0.02 * | - | NS |
| GAA2 | 1.95 (0.84–4.53) | 0.12 | ||
| Heart rate | 1.00 (0.96–1.05) | 0.79 | ||
| Septal wall thickness | 1.41 (1.06–1.89) | 0.02 * | - | NS |
| Posterior wall thickness | 1.14(0.78–1.66) | 0.49 | ||
| Relative wall thickness (RWT) > 0.42 | 5.38 (0.65–44.19) | 0.11 | ||
| LV diastolic diameter | 0.99 (0.88–1.12) | 0.95 | ||
| LV systolic diameter | 1.05 (0.94–1.17) | 0.34 | ||
| LV ejection fraction | 0.88 (0.80–0.98) | 0.02 * | - | NS |
| LV mass index | 1.02 (0.99–1.04) | 0.11 | ||
| Trans mitral E wave | 0.20 (0.01–30) | 0.53 | ||
| Trans mitral A wave | 0.01 (0.00–0.37) | 0.02 * | - | NS |
| E/A ratio | 3.46 (1.30–9.19) | 0.01 * | 3.48 (1.28–9.48) | 0.01 |
| Lateral E/E’ ratio | 1.47 (1.06–2.02) | 0.02 * | 1.64 (1.13–2.40) | 0.01 |
| Left atrial area | 1.20 (1.05–1.36) | 0.006 * | - | NS |
* variables included in the multivariate analysis. NS: non significant.