Table 2.
Inhibitory activities of xanthones 1–3 against tyrosinase, elastase, collagenase, and hyaluronidase.
| Tyrosinase | Elastase | Collagenase | Hyaluronidase | ||||
|---|---|---|---|---|---|---|---|
| Comp. | % Inhibition (150 µM) | IC50 (µM) | % Inhibition (150 µM) | IC50 (µM) | % Inhibition (150 µM) | IC50 (µM) | % Inhibition (150 μM) |
| 1 | 96.17 ± 0.88 | 7.8 ± 0.07 a | 35.2 ± 1.84 a | n.d | 35.77 ± 1.82 a | n.d | n.a. |
| 2 | 84.05 ± 1.87 | 8.93 ± 0.16 b | 10.85 ± 0.39 b | n.d | 26.83 ± 1.45 b | n.d | n.a. |
| 3 | 91.42 ± 0.23 | 3.28 ± 0.01 c | 18.21 ± 0.71 c | n.d | 24.91 ± 0.93 b | n.d | n.a. |
| Kojic acid | - | 12.81 ± 0.01 d | - | - | - | - | - |
| MAAPVCK | - | - | - | 0.26 ± 0.003 | - | - | - |
| EDTA | - | - | - | - | - | 102.95 ± 5.30 | - |
n.a.—Not active (0% inhibition); n.d.—Not determined; Kojic acid (for tyrosinase), MAAPVCK (for elastase), and EDTA (for collagenase) were used as positive controls. In each column, different letters indicate significant differences (p < 0.05).