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. 2020 Jun 1;8(6):831. doi: 10.3390/microorganisms8060831

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Dose-response curves showing the reduction in infection of mouse peritoneal macrophages (PEMs) caused by amphotericin B (a), miltefosine (b), paromomycin (c) and sodium stibogluconate (d) with a variable slope and minimum and maximum set to 0 and 100% respectively. Infection was measured by manual counting using a microscope and the drug-induced percentage reduction of infection was calculated in comparison to untreated controls. Three different experimental conditions resulting in three different media perfusion speeds were used: static (0 m/s), low flow (1.45 × 10⁻⁹ m/s) and high flow (1.23 × 10⁻⁷ m/s). n = 9. Error bars show SD.

Dose-response curves showing the reduction in infection of mouse peritoneal macrophages (PEMs) caused by amphotericin B (a), miltefosine (b), paromomycin (c) and sodium stibogluconate (d) with a variable slope and minimum and maximum set to 0 and 100% respectively. Infection was measured by manual counting using a microscope and the drug-induced percentage reduction of infection was calculated in comparison to untreated controls. Three different experimental conditions resulting in three different media perfusion speeds were used: static (0 m/s), low flow (1.45 × 10⁻⁹ m/s) and high flow (1.23 × 10⁻⁷ m/s). n = 9. Error bars show SD.