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(Left) Dose-response curves for 2D (n = 6) and 3D (n = 6) cell culture showing the reduction in percentage infection of PEMs with L. amazonensis produced by dosing with miltefosine. The percentage reduction in infection calculated based on total infection seen in the untreated controls in either condition. (Right) Reduction in L. amazonensis parasite burden of PEMs for 2D (n = 6) and 3D (n = 6) cell culture, produced by dosing with miltefosine. Error bars show standard deviation.
