Table 10.
EC50 and EC90 values of miltefosine (µM) against the different parasites in different host cell types. Means and 95% confidence intervals are shown.
| iPSC | THP1 | MBMM | HBMM | ||
|---|---|---|---|---|---|
| L. major JISH | EC50 µM | 5.8 (5.2–6.5) | 7.7 (7.5–8.1) | 6.4 (6.1–6.7) | 7.4 (6.9–8.0) |
| EC90 µM | NC | 17.7 (16.5–19.2) | 19.2 (17.4–21.4) | 34.2 (28.5–41.4) | |
| L. major mCherry | EC50 µM | 15.3 (14.2–16.4) | 9.4 (8.5–10.3) | 14.9 (12.2–16.9) | 4.9 (4.1–5.7) |
| EC90 µM | NC | NC | NC | 16.1 (11.3–23.9) | |
| L. amazonensis dsRed | EC50 µM | 76.6 (64.2–94.9) | 28.2 (26.6–30.0) | 25.3 (23.5–27.4) | 14.3 (13.3–15.4) |
| EC90 µM | NC | NC | NC | 62.2 (52.2–75.6) | |
| L. mexicana | EC50 µM | 5.3 (5.0–5.5) | 4.9 (4.6–5.1) | 5.0 (4.7–5.3) | 6.0 (5.3–6.8) |
| EC90 µM | 17.2 (15.6–18.9) | 15.6 (13.9–17.6) | NC | 25.1 (19.7–33.0) |