Fig. 1 –

Development of aortic aneurysm and dissection (AAD) in challenged mice. Mean systolic blood pressure in control and challenged mice during the 4-wk challenge period (A). *P < 0.001. Representative images of an aorta from a control mouse and an aorta from a challenged mouse with suprarenal AAD (B). Cross-section of the aneurysmal suprarenal aorta in a challenged mouse showing dissection between the medial and adventitial layers and thrombus formation in the false lumen (C). ▲ indicates the true aortic lumen. Incidence of AAD and aortic dilatation in different aortic segments of challenged mice (D). FL, false lumen.