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. Author manuscript; available in PMC: 2020 Jul 13.
Published in final edited form as: J Surg Res. 2019 Aug 5;245:1–12. doi: 10.1016/j.jss.2019.07.013

Fig. 8 –

Fig. 8 –

Activation of bone marrow (BM)-derived and resident Sca-1+ stem/progenitor cells in the injured aortic wall. Representative images showing BM-derived Sca-1+ cells in the suprarenal aorta of control and challenged mice (A). ▲ indicates the aortic lumen. White arrows indicate BM-derived Sca-1+ cells. The percentage of BM-derived Sca-1+ cells, resident Sca-1+ cells, and Sca-1+ cells in the total cell population of the suprarenal aorta (*P <0.05 compared with control group) (B) and the percentage of BM-derived Sca-1+ cells in the total Sca-1+ cell population of the suprarenal aorta in challenged and control mice (n = 4 per group) (C). Immunofluorescence staining showing both BM-derived (GFP+) and resident (GFP−) Sca-1+ cells expressing CD68, FSP-1, or NG2 in the aortic adventitia of challenged mice (scale bar = 5 μm) (D). Both BM-derived (GFP+) and resident (GFP−) Sca-1+ cells expressing VEGF, IGF-1, and PDGF-B in the aortic adventitia of challenged mice (scale bar = 5 μm) (E). HFD, high-fat diet.