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. 2020 May 16;7(2):44. doi: 10.3390/bioengineering7020044

Figure 1.

Figure 1

IL-6 and NGF induce an acute and persistent increase in excitability and thermally mediated evoked responses in adult DRG neurons in vitro. (A) Percentage of active electrodes post treatment with 100 ng/mL IL6 + 100 ng/mL NGF or vehicle over 3–72 hours period. (B) Log spike count per well post treatment over a 3–72 hours period. (C) Percentage of temperature responsive electrodes post treatment over a 3–72 hours period. Responsiveness to temperature was defined as an electrode exhibiting a mean firing rate (MFR) of ≥ 2× that of baseline. Temperature stimulus was introduced in the form of base plate heating to a temperature of 42 °C and held for a period of 5 min. An active electrode was defined as an electrode exhibiting a mean firing rate (MFR) of at least 1 spike/min. Error bars are represented as mean ± standard error of the mean (SEM). * p < 0.05, ** p < 0.01, and *** p < 0.001.