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Hypothetical chemopreventive effect of RUT in intestinal mucositis induced by 5-FU. RUT prevents intestinal inflammation by inhibiting MDA, MPO, COX-2, oxidative stress, mastocytosis. RUT also stimulates increased villi and increased levels of the antioxidant GSH. RUT, Rutin; COX-2, Cyclooxygenase 2; MDA, Malondialdehyde; MPO, Myeloperoxidase; GSH, Reduced Glutathione. Green arrows (stimulate/increase), yellow arrows (inhibit).
