Table 2.
Histopathological scores of mice subjected to 5-FU-induced intestinal mucositis and pretreated with RUT.
| Segments | Groups | ||||
|---|---|---|---|---|---|
| Saline | 5-FU | RUT (mg/kg) | |||
| 50 | 100 | 200 | |||
| Duodenum | 0 (0–1) | 3 (2–3) a | 2 (1–3) | 2 (1–2) | 1 (1–3) b |
| Jejunum | 0 (0–1) | 3 (1–3) a | 2 (1–3) | 1.5 (1–3) | 1 (1–2) b |
| Ileum | 0 (0–0) | 3 (1–3) a | 3 (1–3) | 2 (1–3) | 2 (1–3) |
Values are expressed as median, where a p < 0.05 vs. saline and b p < 0.05 vs. 5-FU (n = 6/group). The data were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparisons test. 5-FU, 5-fluorouracil; RUT, rutin.