Figure 3.

Receiver operating characteristic (ROC) curves and optimal cut-off of the following quantitative risk factors associated to moderate-severe AAC (vs. no-mild AAC): age (a), AGEs (b), triglycerides (c) and GFR (d). The optimal cutoff values were determined by the maximum Youden index (J), defined as sensitivity + specificity −1. The table indicate the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall accuracy of the optimal cut off values. Abbreviations. AGEs; advanced glycation end products; GFR: glomerular filtration rate.