Table 2.
Characteristics of studies evaluating ocular coherence tomography angiography in patients with multiple sclerosis.
| Author (Year) | Patients | OCT-A Scan | Main Results |
|---|---|---|---|
| Jiang et al. (2020) | MSNON = 123, MSON = 36, HC = 198 | Macula 3 × 3 | SVD increased in MSNON compared to HC; DVD decreased in MSON compared to MSNON and HC; VVDs * increased in MSON; VVDd * increased in MSNON and MSON |
| Ulusoy et al. (2020) | MSNON + MSON = 20, HC = 24 | NA | SVD reduced in MSNON/MSON compared with HC |
| Feucht et al. (2019) | MSNON = 25, MSON = 17, HC = 50 | Macula 6 × 6 | SVD NS between MSNON compared to HC, decrease in MSON; DVD NS between MSNON compared to HC, decrease in MSON |
| Murphy et al. (2019) | MSNON + MSON = 111, HC = 50 | Macula 3 × 3 | SVD decreased in MSON and MSNON compared to HC, decreased in MSON compared to MSNON, DVD NS between MSNON/MSON and HC and between MSON and MSNON |
| Yilmaz et al. (2019) | MSNON + MSON = 47, HC = 61 | Macula 3 × 3 | SVD decreased in MSNON + MSON compared with HC, decreased in MSON compared with MSNON, DVD decreased in MSNON/MSON compared with HC |
| Lanzillo et al. (2019) | MSNON = 27, MSON = 23, HC = 46 | Macula 6 × 6 | SVD parafoveal increase in MSNON/MSON compared with HC after 1 year follow-up |
| Lanzillo et al. (2018) | MSNON = 27, MSON = 23, HC = 46 | Macula 6 × 6 | SVD decreased parafoveal SVD in MSNON/MSON compared to HC, increased foveal SVD in MSNON/MSON compared to HC |
| Spain et al. (2018) | MSNON + MSON = 45, HC = 32 | ONH 3 × 3 | ONH-FI decreased in MSNON/MSON |
| Wang et al. (2014) | MSNON = 25, MSON = 10, HC = 21 | ONH 3 × 3 | ONH-FI decreased in MSON |
MSNON: multiple sclerosis without history of optic neuritis; MSON: multiple sclerosis with history of optic neuritis; HC: healthy control; ONH: optic nerve head; SVD: vessel density of the superficial vascular plexus; DVD: vessel density of the deep vascular plexus; VVDs: volumetric vessel density in the superficial vascular plexus; VVDd: volumetric vessel density in the deep vascular plexus; NS: not significant; ONH-FI: Optic Nerve Head Flow Index. * based on fractal dimension for VD and VVD.