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. 2020 Jun 25;12(6):592. doi: 10.3390/pharmaceutics12060592

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Pictorial representation of individual and mixed micelle polymer-conjugates of paclitaxel (PTX) and rapamycin (RAP): (A) synthesis schematic for polymeric-paclitaxel conjugate and polymeric-rapamycin conjugate and their micelles formulation, (B) pH-dependent drug release from micelles, (C) accessibility and accumulation of micelles for human umbilical vein endothelial cells HUVECs and cancer cells (ovarian) in the tumor environment [87]. Reprinted with permission from ref. [87], copyright (2016) American Chemical Society.