Figure 12.

(A) Schematic representation of bovine serum albumin-coated superparamagnetic iron oxide (BSA-SPIO) nanoparticles further co-loaded with two drugs (Sun and Cur) to achieve combined cancer therapy. (B) antitumor activity of BSA-SPIOs and drug-loaded BSA-SPIOs in an MCF-7 tumor xenograft mouse model. The mice were treated with free Sun, free Cur, free Sun + Cur, and SPIO-SC every other day by tail vein injection at doses of 15 mg/kg for sun and 30 mg/kg for cur. (a) The growth of tumor volumes, (d) Nude mouse survival time of each group; (e) Nude mouse weight of each group [92]. Reprinted with permission from ref. [92] copyright (2017) Royal Society of Chemistry. * p < 0.05, ** p < 0.01, *** p < 0.001.