Table 4.
Literature overview: Oncological and obstetrical outcomes after NACT and VRT
| Study | Planned NACT+VRT | Underwent NACT+VRT | Adjuvant treatment | Median/mean FU (months) | Fertility preservation n (%) | Recurrences n (%) | Deaths | Attempted pregnancies | Pregnancies | Live births |
|---|---|---|---|---|---|---|---|---|---|---|
| Maneo 2008a 28 | 21 | 16 | 2 (RT) | 69 | 100% | 0 | 0 | 9/16 |
10 in 6 patients |
9 |
| Plante 2011 6, 22 | 4 | 4 | 0 | 95 | 4 (100) | 0 | 0 | 3/4 |
4 |
1 preterm 2 term |
| Singh 2011 23 | 1 | 1 | 1 (CT) | 14 | 1 (100) | 0 | 0 | — | — | — |
| Marchiolè 2018 20 | 19 | 19 |
1 (RT) 2 women refused adjuvant treatment |
63 | 17 (89) | 2/19 (10) | 0 | 6/19 | 8 | 3 term |
| Wang 2013 24 | 2 | 2 | 0 | 84 | 2 (100) | 0 | 0 | 0 | n/a | n/a |
| Lanowska 2014 21 | 20 | 18 | 1 (RT) | 23 | 17 (85) | 1 (5.5) | 0 | 7/7 |
6 1 ongoing |
2 preterm 2 term |
| Robova 2014 9 | 28 | 20 | 0 | 42 | 20 (71) | 4/20 (20) | 2/20 (10) | 12/20 |
10 |
In 8 women: 6 term 4 preterm |
| Hauerberg 2015 25 | 1 | 1 | 0 | 68 | 1 (100) | 0 | 0 | — | — | — |
| Our report 2019 | 18 | 14 | 0 | 49.7 | 14 (18) | 3/14 (21) | 0 | 6/4 | 6 | 3 live births |
Abbreviations: —, unknown; CT, chemotherapy; FU, follow‐up; n/a, not applicable; NACT, neoadjuvant chemotherapy; RT, radiotherapy; VRT, vaginal radical trachelectomy.
a
Cold knife conization, max 3 cm diameter of tumor before treatment.