Table 1.

The half maximal inhibitory concentration (IC₅₀) after exposure of 10, CO-1686 or gefitinib to non-small cell lung cancer (NSCLC) cell lines by 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H tetrazolium monosodium salt (WST-8) assay.

Cell Lines	Mutation Status	IC50 (μM)
		10	CO-1686	Gefitinib
H1975	L858R/T790M	0.20 ± 0.05	0.14 ± 0.05	>10
H3255	L858R	0.50 ± 0.21	0.15 ± 0.02	0.02 ± 0.02
H441	Wild-type	1.84 ± 0.44	0.26 ± 0.04	>10

Data represent the mean ± SD of three separate experiments.