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Inhibition activities to epidermal growth factor receptor (EGFR) tyrosine kinases (wild-type and L858R/T790M mutations).
| Compound | IC50 Value (μM) | SI (WT: L858R/T790M) | |
|---|---|---|---|
| Wild-Type (WT) | L858R/T790M | ||
| CO-1686 | 1.68 ± 0.15 | 0.04 ± 0.01 | 42 |
| 10 | >10 | 0.31 ± 0.15 | >32 |
Data represent the mean ± SD of three separate experiments.
