Table 1.
Lipid profile and hepatic parameters of low-density lipoprotein receptor knockout mice (LDLR-KO) after eight weeks on a western diet.
| Controls | Scramble | d-[113–122]apoJ | |
|---|---|---|---|
| Total cholesterol (mM) | 52.5 ± 8.2 | 50.7 ± 7.7 | 51.9 ± 7.6 |
| VLDL-c (mM) | 39.3 ± 8.2 | 36.5 ± 7.5 | 34.9 ± 8.0 |
| LDL-c (mM) | 9.6 ± 2.0 | 10.4 ± 3.8 | 13.6 ± 4.0 |
| HDL-c (mM) | 3.5 ± 1.5 | 3.3 ± 0.9 | 3.5 ± 1.8 |
| Triglycerides (mM) | 9.6 ± 2.2 | 7.8 ± 3.1 | 7.9 ± 3.5 |
| Phospholipids (mM) | 10.8 ± 0.5 | 10.6 ± 1.5 | 10.2 ± 1.8 |
| AST (U/L) | 107.4 ± 71.4 | 110.3 ± 70.9 | 86.8 ± 47.6 |
| ALT (U/L) | 29.3 ± 20.2 | 38.4 ± 25.5 | 22.1 ±11.0 |
| Liver weight (g) | 1.48 ± 0.23 | 1.34 ± 0.32 | 1.33 ± 0.22 |
| Liver cholesterol (µmol/g liver) | 9.50 ± 4.67 | 11.57 ± 4.25 | 10.84 ± 3.63 |
| Liver triglycerides (µmol/g liver) | 12.42 ± 3.98 | 15.43 ± 3.05 | 11.51 ± 3.89 |
| Liver phospholipids (µmol/g liver) | 4.62 ±1.97 | 4.30 ± 1.75 | 4.64 ±1.43 |
Data are expressed as mean ± SD, n = 8 (controls and scramble), n = 12 (peptide). VLDL: very-low-density lipoprotein, LDL: low-density lipoprotein, HDL: high-density lipoprotein, AST: aspartate transaminase, ALT: alanine transaminase, SD: standard deviation.