Figure 5.

BML-111 prevents UVB irradiation-induced collagen degradation. Degradation of collagen was determined in samples dissected 12 h after the radiation and stained with Masson’s trichrome. Representative images of non-irradiated control (A), irradiated treated with vehicle (B), irradiated treated with 0.1 mg/kg of BML-111 (C), irradiated treated with BOC and BML-111 (D), and irradiated treated with BOC (E) groups are presented. Quantitative analysis of collagen degradation of experimental groups is presented as percentage of staining in panel (F). Original magnification 10×; 100 μm. Results are expressed as mean ± SEM and are representative of two independent experiments. One-way ANOVA followed by Tukey’s post-test * p < 0.05 compared to non-irradiated group, # p < 0.05 compared to irradiated vehicle-treated group, ## p < 0.05 compared to BML-111 group.