Figure 5.

Basal spontaneous contraction activity (BSCA) in the colon. Zero represents the basal tone and each point is the percent variation from the baseline after cumulative addition of each dose. (A) EO, SEO and excipients (mg/mL); numbers in brackets represent the effective EO concentration (mg/mL) in SEO. (B) Otilonium bromide (OB) (µg/mL), an antispasmodic drug, used as a positive control. Each value (expressed as percent variation) is the mean ± SEM; when the error bar is not shown, it is covered by the point.