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. 2020 Jun 7;9(6):1770. doi: 10.3390/jcm9061770

Figure 4.

Figure 4

Silibinin is predicted to target SARS-CoV-2 viral polymerase RdRp (II). Representations of the SARS-CoV-2 viral polymerase RdRp in non-reduced (6M71) and reduced (7BTF) conditions showing the computationally predicted locations of silibinin, remdesivir, ribavirin, and sofosbuvir clusters in the nsp12 catalytic subunit of the nsp12-nsp7-nsp8 complex. The protein has been represented as a function of the hydrophobicity of its surface amino acids and the Na+ and Cl- ions have been eliminated to facilitate visualization. Figures were prepared using PyMol 2.3 software.