Table 1.

Binding affinity of IDB0076 for VEGFA and neuropilin-1 (NRP1) according to the Biacore system.

Immobilized Antigen		Analyte	ka (M−1s−1)	kd (s−1)	KD (M)
Protein	Species
NRP1 ECD	Human	IDB0076	1.221 × 105	1.921 × 10−3	1. 574 × 10−8
NRP1 ECD	Mouse	IDB0076	1.885 × 105	4.142 × 10−3	2.197 × 10−8
VEGFA	Human	IDB0076	2.904 × 104	3.491 × 10−5	1.202 × 10−9
VEGFA	Human	Bevacizumab	3.099 × 104	4.457 × 10−5	1.438 × 10−9

ECD: extracellular domain; k_a: association rate constant; k_d: dissociation rate constant; K_D: equilibrium dissociation rate constant.