Table 3.

Blood chemistry in cynomolgus monkeys that received IDB0076.

Sex	Dose	AST (IU/L)			ALT (IU/L)			ALP (IU/L)			GGT (IU/L)
		Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery
Males	2 mg/kg	66	53	N/A	54	43	N/A	1912	2038	N/A	70	80	N/A
	10 mg/kg	30	55	N/A	34	47	N/A	1223	1102	N/A	58	59	N/A
	50 mg/kg	27	44	N/A	21	21	N/A	1166	1265	N/A	67	97	N/A
	50 mg/kg-recovery	34	34	27	33	24	21	1178	1107	1412	48	57	52
Females	2 mg/kg	43	50	N/A	83	76	N/A	694	613	N/A	56	54	N/A
	10 mg/kg	44	35	N/A	108	44	N/A	554	466	N/A	52	52	N/A
	50 mg/kg	30	46	N/A	40	45	N/A	677	882	N/A	45	54	N/A
	50 mg/kg-recovery	42	104	34	71	53	35	822	1124	674	43	53	38
Sex	Dose	Creatinine (mg/dL)			CK (IU/L)			Total bilirubin (mg/dL)			Urea nitrogen (mg/dL)
		Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery
Males	2 mg/kg	0.66	0.60	N/A	377	198	N/A	0.07	0.10	N/A	34.3	30.3	N/A
	10 mg/kg	0.69	0.66	N/A	254	452	N/A	0.17	0.25	N/A	19.4	18.4	N/A
	50 mg/kg	0.85	0.82	N/A	188	156	N/A	0.11	0.08	N/A	22.0	22.6	N/A
	50 mg/kg-recovery	0.58	0.58	0.58	174	111	118	0.12	0.13	0.08	17.8	18.2	21.1
Females	2 mg/kg	0.53	0.49	N/A	199	254	N/A	0.21	0.12	N/A	16.3	22.0	N/A
	10 mg/kg	0.65	0.59	N/A	177	160	N/A	0.14	0.13	N/A	18.2	17.4	N/A
	50 mg/kg	0.71	0.78	N/A	378	133	N/A	0.17	0.18	N/A	23.7	22.5	N/A
	50 mg/kg-recovery	0.60	0.63	0.64	187	529	364	0.15	0.12	0.13	16.8	16.7	15.4
Sex	Dose	Glucose (mg/dL)			IP (mg/dL)			TP (g/dL)			Albumin (g/dL)
		Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery
Males	2 mg/kg	78	83	N/A	4.98	4.80	N/A	7.6	7.0	N/A	3.8	3.5	N/A
	10 mg/kg	75	72	N/A	6.50	4.81	N/A	7.6	7.2	N/A	4.1	3.7	N/A
	50 mg/kg	85	78	N/A	5.67	3.12	N/A	6.8	7.8	N/A	3.6	3.5	N/A
	50 mg/kg-recovery	85	83	79	5.53	3.79	4.36	7.9	8.2	7.5	4.1	3.8	3.7
Females	2 mg/kg	78	73	N/A	4.99	3.46	N/A	7.4	7.0	N/A	4.4	4.0	N/A
	10 mg/kg	59	63	N/A	6.00	4.19	N/A	7.6	7.1	N/A	3.6	3.5	N/A
	50 mg/kg	66	61	N/A	5.36	3.46	N/A	7.6	7.6	N/A	4.0	3.5	N/A
	50 mg/kg-recovery	80	76	71	4.65	2.61	4.33	7.8	8.0	7.8	4.3	3.5	4.1
Sex	Dose	Globulin (g/dL)			Albumin/globulin ratio			TG (mg/dL)			Total cholesterol (mg/dL)
		Pre	End of dosing	End of recovery	Pre	End of dosing	End of recovery	Pre	End of Dosing	End of recovery	Pre	End of dosing	End of Recovery
Males	2 mg/kg	3.8	3.5	N/A	1.00	1.00	N/A	103	67	N/A	123	120	N/A
	10 mg/kg	3.5	3.5	N/A	1.17	1.06	N/A	29	24	N/A	158	172	N/A
	50 mg/kg	3.2	4.3	N/A	1.13	0.81	N/A	37	46	N/A	168	177	N/A
	50 mg/kg-recovery	3.8	4.4	3.8	1.08	0.86	0.97	32	18	38	135	147	128
Females	2 mg/kg	3.0	3.0	N/A	1.47	1.33	N/A	39	96	N/A	92	87	N/A
	10 mg/kg	4.0	3.6	N/A	0.90	0.97	N/A	63	35	N/A	156	162	N/A
	50 mg/kg	3.6	4.1	N/A	1.11	0.85	N/A	40	57	N/A	127	223	N/A
	50 mg/kg-recovery	3.5	4.5	3.7	1.23	0.78	1.11	47	31	26	148	196	148

ALP: alkaline phosphatase, ALT: alanine transaminase, AST: aspartate transaminase, CK: creatine kinase, GGT: γ-glutamyltransferase, IP: inorganic phosphorus, N/A: not applicable, TG: triglycerides, TP: total protein.