. 2020 Jun 22;10(6):937. doi: 10.3390/biom10060937

Table 1.

List of lncRNAs whose expression has been downregulated in SLE patients (PBMC: peripheral blood mononuclear cell, SPF BALB/c mice: specific pathogen-free (SPF) bcl-2 transgenic BALB/c mice).

LncRNA	Number of Clinical Samples (Tissues, Serum, etc.)	Assessed Cell Line	Targets/Regulators	Signaling Pathways	Function and Comments	Reference
lnc-HSFY2-3:3	15 SLE patients and 15 healthy donors were enrolled.	Monocyte-derived dendritic cells (moDCs)				[18]
lnc-SERPINB9-1:2	15 SLE patients and 15 healthy donors were enrolled.	Monocyte-derived dendritic cells (moDCs)				[18]
GAS5	24 SLE patients and 12 healthy controls were enrolled.	Plasma			GAS5 induces apoptosis and growth arrest in human peripheral blood T cells and increases apoptosis.	[20]
lnc-DC	24 SLE patients and 12 healthy controls were enrolled.	Plasma	STAT3		Lnc-DC, which is expressed exclusively in dendritic cells, supports their capacity to stimulate T cell activation.	[20]
PRSS30P	5 SLE patients and 6 age- and gender-matched normal individuals were enrolled in this study.	Plasma				[21]
RP11-23P13.6
ARRDC1-AS1
RP4-758J18.2			CCNL2		The downregulation of RP4-758J18.2 and CCNL2 may play a key role in the immune response of SLE.
RP11-66N24.3
LINC00996			REPIN1
RP11-649A18.12			NUP85, MIF4GD
RP11-539L10.2			MAN2B2
RP11-23J9.5
TMEM147-AS1
lnc5150	76 SLE patients and 71 healthy controls were recruited in this study.	PBMCs			Lnc5150 might disclose a diagnostic value for SLE.	[23]
linc0949	Samples were obtained from 102 SLE patients and 76 healthy donors.	PBMCs	TNF-α, IL-6		Linc0949 could be a potential biomarker for diagnosis, disease activity and therapeutic response in SLE.	[24]
CTC-471J1.2	Samples were collected from 29 SLE patients and 34 age- and sex-matched healthy control subjects.	PBMCs				[19]
TUG1	Samples from 85 SLE patients and 95 healthy controls were collected.	PBMCs	miR-223		TUG1 might be associated with inflammation and renal injury in SLE pathogenesis.	[26]
TUG1	A total of 24 SPF BALB/c female mice (8 weeks old) (SLE models: n = 18, controls: n = 6).	Blood samples, kidney tissue	p65	NF-κB signaling pathway	Inhibition of NF-κB signaling might be a potential target in SLE treatment.	[25]
SLEAR	130 SLE patients and 119 healthy controls were enrolled.	Jurkat cells	ILF2, hnRNP F and TAF15		SLEAR expression negatively correlates with degree of apoptosis in SLE patients.	[28]
uc001ykl.1	24 SLE patients and 12 age-matched healthy volunteers were recruited.	T cells	CDK6		A decreased uc001ykl.1 level may induce CRISPLD2 downregulation and then result in inflammation and abnormalities of the erythrocyte sedimentation rate (ESR) and CRP.	[27]
ENST00000448942		T cells	TNFSF10, TNFAIP3		The correlation between ENST00000448942 and ESR may be due to its potential role in positively regulating expression of TNFAIP3, an important regulator of inflammation.	[27]