Table 2.
Phenotypic antimicrobial resistance-related genotype distribution and allele frequencies.
| Mutation * | Corresponding Allele | Frequency, n (%) | Mutant: Wild Type (Frequency, %) | p-Value | |
|---|---|---|---|---|---|
| Susceptible | Resistant | ||||
| 387G>A (383) | A | 1 (2.2) | 0:8 (0) | 1:37 (2.6) | >0.999 |
| 471T>G (467) | T | 16 (34.8) | 5:3 (62.5) | 27:11 (71.1) | 0.684 |
| 496A>G (492) | G | 1 (2.2) | 0:8 (0) | 1:37 (2.6) | >0.999 |
| 512C>T (508) | T | 8 (17.4) | 1:7 (12.5) | 7:31 (18.4) | >0.999 |
| 724A>G (720) | A | 15 (32.6) | 4:4 (50.0) | 27:11 (71.1) | 0.407 |
| 762_763insT (758) | No ins | 14 (30.4) | 5:3 (62.5) | 27:11 (71.1) | 0.684 |
| 763A>T (759) | T | 24 (52.2) | 1:7 (12.5) | 23:15 (60.5) | 0.020 |
| 764C>T (760) | T | 10 (21.7) | 0:8 (0) | 10:28 (26.3) | 0.171 |
| 808C>T (804) | C | 4 (8.7) | 6:2 (75.0) | 36:2 (94.7) | 0.134 |
| 870G>A (866) | G | 2 (4.3) | 7:1 (87.5) | 37:1 (97.4) | 0.321 |
| 977C>A (973) | C | 8 (17.4) | 6:2 (75.0) | 32:6 (84.2) | 0.613 |
| 977C>G (973) | C | 4 (8.7) | 7:1 (87.5) | 35:3 (92.1) | 0.548 |
| 977C>T (973) | C | 13 (28.3) | 5:3 (62.5) | 28:10 (73.7) | 0.669 |
| 1027G>A (1023) | A | 23 (50.0) | 3:5 (37.5) | 20:18 (52.6) | 0.700 |
| 1516dupT (1512) | TT | 6 (13.0) | 1:7 (12.5) | 5:33 (13.2) | >0.999 |
| 1517G>A (1513) | A | 29 (63.0) | 5:3 (62.5) | 24:14 (63.2) | >0.999 |
| 1550C>T (1546) | T | 2 (4.3) | 0:8 (0) | 2:36 (5.3) | >0.999 |
| 1568C>T (1564) | T | 18 (39.1) | 2:6 (25.0) | 16:22 (42.1) | 0.453 |
| 1582C>T (1578) | C | 1 (2.2) | 7:1 (87.5) | 38:0 (100.0) | 0.174 |
| 1583G>A (1579) | G | 1 (2.2) | 7:1 (87.5) | 38:0 (100.0) | 0.174 |
| 1648T>C (1644) | T | 37 (80.4) | 0:8 (0) | 9:29 (23.7) | 0.324 |
| 1705C>T (1701) | T | 4 (8.7) | 0:8 (0) | 4:34 (10.5) | >0.999 |
| 1759C>T (1755) | C | 4 (8.7) | 6:2 (75.0) | 36:2 (94.7) | 0.134 |
| 2088C>G (2084) | T | 3 (6.5) | 0:8 (0) | 3:35 (7.9) | >0.999 |
| 2146A>G (2142) | G | 2 (4.3) | 0:8 (0) | 2:36 (5.3) | >0.999 |
| 2147A>G (2143) | G | 36 (78.3) | 0:8 (0) | 36:2 (94.7) | <0.001 |
| 2186T>C (2182) | C | 42 (91.3) | 6:2 (75.0) | 36:2 (94.7) | 0.134 |
| 2194T>C (2190) | C | 4 (8.7) | 0:8 (0) | 4:34 (10.5) | >0.999 |
| 2227A>G (2223) | A | 1 (2.2) | 7:1 (87.5) | 38:0 (100.0) | 0.174 |
| 2292C>T (2288) | T | 1 (2.2) | 0:8 (0) | 1:37 (2.6) | >0.999 |
| 2439A>G (2434) | G | 7 (15.2) | 0:8 (0) | 7:31 (18.4) | 0.325 |
| 2716T>C (2711) | C | 4 (8.7) | 0:8 (0) | 4:34 (10.5) | >0.999 |
| 2764C>T (2759) | C | 6 (13.0) | 6:2 (75.0) | 34:4 (89.5) | 0.277 |
| 2868G>A (2860) | G | 44 (95.7) | 0:8 (0) | 2:36 (5.3) | >0.999 |
| 2921G>A (2913) | G | 36 (78.3) | 0:8 (0) | 10:28 (26.3) | 0.171 |
| 2924C>T (2916) | T | 14 (30.4) | 1:7 (12.5) | 13:25 (34.2) | 0.403 |
| 2926C>T (2918) | T | 5 (10.9) | 0:8 (0) | 5:33 (13.2) | 0.569 |
| 2929T>C (2921) | C | 13 (28.3) | 2:6 (25.0) | 11:27 (28.9) | >0.999 |
After Bonferroni correction, p-value of < 0.0012 is considered statistically significant. * Numbers in parentheses indicate equivalent nucleotide position proposed by Taylor et al. [20].