Table 3.

Examples recently developed pH-responsive nanocarriers with potentials for parenteral drug delivery.

Type of the Nanocarrier	pH Responsive Moiety	Incorporated Cargo	Application	Reference
Layer-by-layer assembled nanoparticles	Neutravidin-iminobiotin bond	Quantum Dots	Stealth coating shedding, cancer therapy	[181]
Lipid core nanoparticles	polyethylene glycol-b-polyaspartic acid	Docetaxel	Stealth coating shedding, cancer therapy	[182]
Polymeric nanospheres	poly- (1,4-phenyleneacetone dimethylene ketal)	Dexamethasone	Intracellular drug release	[184]
Drug-polymer conjugate	Cleavable amide bond	Doxorubicin	Intracellular drug release, cancer therapy	[187]
Drug-polymer conjugate	Hydrazone bond	Doxorubicin	Intracellular drug release, cancer therapy	[188]
Cyclodextrin-derived nanoparticles	Poly(cyclohexane-1, 4-diyl acetone dimethylene ketal)	Paclitaxel	Intracellular drug release, cancer therapy	[189]
Drug-polymer conjugate	Hydrozone bond	Cisplatin	Intracellular drug release, cancer therapy	[190]
Mesoporpous silica nanoparticle	Hydrozone bond	Doxorubicin	Intracellular drug release, cancer therapy	[191]
Polymeric micelles	Poly(β-amino ester)	Doxorubicin	Intracellular drug release, cancer therapy	[192]
Nanogels	Amino groups	Oridonin	Intracellular drug release, Drug release in tumor extracellular environment, cancer therapy	[193]
Polymeric micelles	N-Boc-histidine	Doxorubicin	Drug release in tumor extracellular environment, cancer therapy	[179]
Polymeric micelles	Poly(β-amino ester)	Doxorubicin	Drug release in tumor extracellular environment, cancer therapy	[180]
Polymeric nanoparticles	Chitosan	Camptothecin	Drug release in tumor extracellular environment, cancer therapy	[194]
polymeric micelles	poly(beta-amino ester)	Doxorubicin	Drug release in tumor extracellular environment, cancer therapy	[195]
Flower-like polymeric micelle	poly(DEAP-Lys)	Doxorubicin	Drug release in tumor extracellular environment, cancer therapy	[196]
Micelle-like nanoparticles	Poly(N- methacryloyl-l-valine) and poly(N-methacryloyl-L-phenylala- nine)	-	-	[197]