Table 1.
Calculation of the synergy between ursolic acid and quercetin in the 2D migration assay. Data are presented as the mean ± SD (triplicates of three separate passages).
| Ratios | Quercetin µM | Ursolic Acid µM |
Relative Migration | Combination Index |
Relative Synergy 1 |
|---|---|---|---|---|---|
| n/a | 125 | 0 | 50% | n/a | n/a |
| n/a | 0 | 13.7 | 50% | n/a | n/a |
| IC50 | 125 | 13.7 | 24% | 0.90-1.10 | ± |
| IC50/2 | 65.5 | 6.85 | 34% | 0.7-0.85 | ++ |
| IC50/4 | 31.25 | 3.42 | 44% | 0.3-0.7 | +++ |
| IC50/8 | 15.62 | 1.71 | 52% | 0.3-0.7 | +++ |
1 (±) Nearly additive; (++) Moderate Synergism; (+++) Synergism [26].