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. 2020 Jun 17;25(12):2805. doi: 10.3390/molecules25122805

Table 1.

Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitory potency of the compounds.

Inline graphic
(3, 23, 26, 27)		 Inline graphic
(21a-21c, 21e, 21n)
Compound R1 IC50 (μM) a Compound R2 IC50 (μM)
3 graphic file with name molecules-25-02805-i003.jpg 17 ± 2 21a graphic file with name molecules-25-02805-i004.jpg 680 ± 90
27 graphic file with name molecules-25-02805-i005.jpg NI b 21b graphic file with name molecules-25-02805-i006.jpg NI b
(±)-23 graphic file with name molecules-25-02805-i007.jpg 192 ± 53 21n graphic file with name molecules-25-02805-i008.jpg 95 ± 14
26 graphic file with name molecules-25-02805-i009.jpg 230 ± 63 21c graphic file with name molecules-25-02805-i010.jpg 100 ± 15
21e graphic file with name molecules-25-02805-i011.jpg 160 ± 22

a Values for which standard deviations are given are the calculated mean values of at least two measurements. b NI: no inhibition at a concentration of 0.2 mM.