Table 3.
Antimycobacterial activity against H37Rv and cytotoxicity against MRC-5 fibroblasts of the compounds in this study.
| Compound | MIC a
(H37Rv, μM) |
IC50
(MRC-5, μM) |
SI b | Compound | MIC (H37Rv, μM) |
IC50
(MRC-5, μM) |
SI |
|---|---|---|---|---|---|---|---|
| 3 | 37 | >64 | >1.73 | 21k | ≥50 | >64 | - |
| 21a | >50 | >64 | - | 21l | 37 | >64 | >1.73 |
| 21b | >50 | 22.22 | - | 21m | 37 | >64 | >1.73 |
| 21c | 50 | 26.81 | 0.54 | 21n | 37 | 27.57 | 0.74 |
| 21e | >50 | >64 | - | 21o | 19 | 7.08 | 0.37 |
| 21f | 19 | 8.42 | 0.44 | 21p | 12.5 | 4.22 | 0.34 |
| 21g | 19 | 5.66 | 0.30 | 21q | 25 | 19.84 | 0.79 |
| 21h | 12.5 | 5.81 | 0.46 | 23 | >50 | 21.77 | - |
| 21i | 25 | >64 | >2.56 | 26 | >50 | >64 | - |
| 21j | 19 | 25.24 | 1.33 | 27 | 6.25 | 8.06 | 1.29 |
a Minimum inhibitory concentration (MIC) is the minimum concentration required to inhibit >99% growth of Mycobacterium tuberculosis H37Rv in the liquid culture. b Selectivity index (SI): IC50 (MRC-5)/MIC (H37Rv).